p53 tumour suppressor
نویسندگان
چکیده
Other speculated functions include1⁄4 does it really need more? Well, it seems to function in multicellular development and differentiation, too, and there’s some evidence that it’s an exonuclease. If you’re beginning to think that researchers from all areas of biology are obsessed with p53, witness the number of grant applications claiming that studies of p53 will provide a cure for cancer, explaining the cell cycle, DNA repair and morphogenesis along the way.
منابع مشابه
p53 tumour suppressor gene expression in pancreatic neuroendocrine tumour cells.
Neuroendocrine pancreatic tumours grow slower and metastasise later than ductal and acinar carcinomas. The expression of the p53 tumour suppressor gene in pancreatic neuroendocrine tumour cells is unknown. Pancreatic neuroendocrine cell lines (n = 5) and human tumour tissues (n = 19) were studied for changed p53 coding sequence, transcription, and translation. Proliferative activity of tumour c...
متن کاملTumour Biology: p53 Gene Mechanisms
Tumour is a sum of genetic errors with constantly proliferating cells. Development of cancer requires altered mechanism in just one cell resulting in unlimited replication of that cell. Inspite of several genetic insults that occur there are few cells which turn neoplastic. Thus, suggesting of a very powerful protective mechanism at work. p53, a tumour suppressor gene, is cancer prophylactic fo...
متن کاملTumour suppressor protein (p53), apoptosis inhibiting protein (Bcl-2) and proliferating cell nuclear antigen (PCNA) expressions in a rat pancreatic tumour model.
BACKGROUND Previous studies have shown that, cultured rat pancreatic carcinoma cells, derived from azaserine-induced acinar tumours, yield tumours with a ductal phenotype. MATERIALS AND METHODS In order to find out the molecular characteristics of this tumour model, tumour suppressor protein (p53), apoptosis inhibiting protein (Bcl-2) and proliferating cell nuclear antigen (PCNA) expressions ...
متن کاملThe structure of p53 tumour suppressor protein reveals the basis for its functional plasticity.
p53 major tumour suppressor protein has presented a challenge for structural biology for two decades. The intact and complete p53 molecule has eluded previous attempts to obtain its structure, largely due to the intrinsic flexibility of the protein. Using ATP-stabilised p53, we have employed cryoelectron microscopy and single particle analysis to solve the first three-dimensional structure of t...
متن کاملPolymorphisms in p53 and the p53 pathway: roles in cancer susceptibility and response to treatment
The p53 tumour suppressor protein lies at the crossroads of multiple cellular response pathways that control the fate of the cell in response to endogenous or exogenous stresses and inactivation of the p53 tumour suppressor signalling pathway is seen in most human cancers. Such aberrant p53 activity may be caused by mutations in the TP53 gene sequence producing truncated or inactive mutant prot...
متن کاملTumour suppressor p53: understanding the molecular mechanisms inherent to cancer
Tumour suppressor p53 has been the centre of focus of researchers trying to decipher the molecular mechanisms underlying tumourigenesis. In this review, we have summarized the critical role of p53 in tumour suppression through its effects on several cellular processes such as DNA repair, cell cycle and apoptosis. We have also discussed the role of upstream regulators which sensitize p53 to resp...
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ورودعنوان ژورنال:
- Current Biology
دوره 8 شماره
صفحات -
تاریخ انتشار 1998